A New Constitutively Active Brain PAK3 Isoform Displays Modified Specificities toward Rac and Cdc42 GTPases
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چکیده
منابع مشابه
Rac and Cdc42 GTPases control hematopoietic stem
Critical to homeostasis of blood cell production by hematopoietic stemyprogenitor (HSCyP) cells is the regulation of HSCyP retention within the bone marrow microenvironment and migration between the bone marrow and the blood. Key extracellular regulatory elements for this process have been defined (cell–cell adhesion, growth factors, chemokines), but the mechanism by which HSCyP cells reconcile...
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P21-activated kinase 1 (PAK1) is activated by binding to GTP-bound Rho GTPases Cdc42 and Rac via its CRIB domain. Here, we provide evidence that S79 in the CRIB domain of PAK1 is not directly involved in this binding but is crucial for PAK1 activation. S79A mutation reduces the binding affinity of PAK1 for the GTPases and inhibits autophosphorylation and kinase activity of PAK1. Thus, this muta...
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456 8 Pollard, T. (1986) J. Cell Biol. 103,2747-2754 9 Janmey, P. A. and Stossel, T. P. (1986) J. Muscle Res. Cell Motil. 7,446-454 10 Heacock, C. and Bamburgh, J. (1983) Anal. Biochem. 135,22-36 11 Korn, E. (1978) Proc. Natl. Acad. Sci. USA. 75. 588-599 12 Hartwig, J. and Kwiatkowski, D. (1991) Curr. Opin. Cell Biol. 3, 87-97 13 Safer, D., Elzinga, M. and Nachmias, V. T. (1991) J. Biol. Chem. ...
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Cell adhesion to extracellular matrix is an important physiological stimulus for organization of the actin-based cytoskeleton. Adhesion to the matrix glycoprotein thrombospondin-1 (TSP-1) triggers the sustained formation of F-actin microspikes that contain the actin-bundling protein fascin. These structures are also implicated in cell migration, which may be an important function of TSP-1 in ti...
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Cross-talk between Rho GTPase family members (Rho, Rac, and Cdc42) plays important roles in modulating and coordinating downstream cellular responses resulting from Rho GTPase signaling. The NADPH oxidase of phagocytes and nonphagocytic cells is a Rac GTPase-regulated system that generates reactive oxygen species (ROS) for the purposes of innate immunity and intracellular signaling. We recently...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m207251200